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Transfusion-transmitted virus, injection drug users, hepatitis

Abstract number: 1733_554

Soudbakhsh A., Hajabdolbaghi M., Mohraz M., Abdollahi Nami M., Khairandish P., Emadi Koochak H.

Objective: Transfusion-Transmitted Virus (TTV) is a nonenveloped, single-stranded and circular DNA virus which is belongs to the genus Anellovirus of circuviridae family. It was discovered by Nishizawa in 1997. One of the most important ways of transmission is use of common syringes. An increase in the population of Injection drug users (IDU) can be dangerous to other persons who are not IDUs. The objective of this study was to determine the prevalence of TTV in the IDU population of Iran.

Materials and Methods: In this cross-sectional study which was performed at the Infectious ward of Imam Khomeini hospital, 60 IDU patients were studied. Blood samples were dispatched to the lab in citrated test tubes for Virus isolation, using the boiling method, and then PCB assay performed based on available primers. The patient's information gathered by interview and questionnaire methods. Statistical tests such as Pearson Chi-Square, Mann Whitey and T-test used to analyze these data.

Results: All our 60 patients were men and their age average was 35.3 years (SD±9.68). Twenty-six patients had positive TTV PCR and 92.3% of them had history of imprisonment. Of these 26 patients, 88.5% had positive HCV Ab, 65.4% had positive HIV Ab and 30.8% had positive HBS Ag. In the 60 patients studied, 80% had positive HCV Ab, 71.7% had positive HIV Ab, 43% had TTV PCR and 26.7% had positive HBS Ag.

Out of 26 patients who had TTV, 34.60% of them had no overt sickness and 11.5% of them displayed signs of hepatitis (fever, abdominal pain, nausea, vomiting, right upper quadrant tenderness and icter). Liver function test was abnormal in 34.6% The average years of injection in the 26 TTV patients was 9 years (SD±7.16) and the patient's age average was 36.35 years (SD±9.2).

Conclusion: One of the most important ways of TTV infection is needle sharing. By this rout chance of TTV infection is less than HIV and HCV but more than HBV. Due to the high prevalence of TTV infection in the IDU population in our country and the fact that this population is not limited and there is no comprehensive information about pathogenesis of this virus, which is faecal–oral, there is a need to make plans and adopt policies to decrease the danger of transmission of this virus to healthcare workers and their families as well as other near relatives.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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