Epidemiological, clinical and serological features of human leptospirosis in Bulgaria in 2005

Abstract number: 1733_549

Taseva E., Christova I., Gladnishka T.

Objectives: Leptospirosis is a worldwide distributed zoonosis that affects humans and is now identified as one of the emerging infectious diseases. The present study aims to summarise incidence, epidemiology, clinical symptoms, circulating serovars, mode of transmission, and source of infection in laboratory confirmed human leptospirosis cases reported to the Bulgarian Ministry of Health for 2005 year.

Methods: All patients were diagnosed using the reference method for serological diagnosis, i.e. microscopic agglutination assay. Suspensions of live serovars from 9 different Leptospira serogroups were used as antigens.

Results: A total of 43 confirmed and reported leptospirosis cases for 2005 year, were analyzed. The average incidence of the disease was 0.55/100 000. The overall fatality rate was 11.63%, which is higher than in the previous study. The most cases were reported from north-eastern regions (Shumen – 27.91%) and north-western (Montana – 11.63% and Lovech – 9.30%) regions of the country. The disease affected mainly men. Cases occurred in all age groups, but were more common the men of working age (51–60 years) – 31.75%. The typical leptospiral seasonal course, with a peak in October, was observed. The infection was acquired through occupational (48.84%), recreational (30.24%) and accidental (20.93%) exposure. The most frequently reported symptoms were fever (38.46%), icterus (36.54%), myalgia, headache, hepatomegaly and splenomegaly. Serovars belonging to 6 different serogroups caused infection during the study period. Two serogroups, Icterohaemorrhagiae (48.70%) and Pomona (32.17%) accounted for most of leptospirosis cases. The third main cause of infection was serogroups Bataviae and Sejroe (6.96%).

Conclusions: The analysis of the data showed that measures for rodent control are still inefficient. Clinical data showed prevalence of the icteric clinical form of the disease and serological finding revealed prevalence of serogroup Icterohaemorrhagiae. Knowledge of epidemiological, clinical, and serological features of leptospirosis is an appropriate base to outline measures for successful prevention and early diagnosis of the disease.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
Back to top