Antibody response in Crimean-Congo haemorrhagic fever, and association between antibodies and clinical outcome

Abstract number: 1733_537

Özkurt Z., Özden K., Kadanali A., Erol S., Yilmaz N., Parlak M.

Objectives: Crimean-Congo haemorrhagic fever is a serious viral disease. Fatality rate of the disease has been reported as 5–50%. The neutralising antibody response is weak and difficult to demonstrate in CCHF infection. In this study we aimed detection of antibody response in the disease and association between clinical outcome.

Methods: We evaluated 90 confirmed CCHF cases. Microbiological diagnosis and confirmation of the disease were made by demonstrating seroconversion, by IgM antibody, and/or polymerase chain reaction (PCR). IgM and IgG antibodies were detected by ELISA.

Results: Anti-CCHFV IgM antibody was detected in 4 of 10 (40%) fatal cases versus 54 of 90 (60%) survivors (p < 0.05). Anti-CCHFV IgG antibody was not detected in any fatal case (0/10) but it was found positive in 35 of 76 (46%) survivors (p < 0.05).

Conclusion: These data show that antibody response is low in fatal cases than those of survivors. Neutralising activity may have an important role of limitation of the disease, and the value of immune sera in therapy should be investigated in further studies.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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