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Evaluation of the role of Chlamydia trachomatis in chronic prostatic infection

Abstract number: 1733_420

Ouzounova-Raykova V., Mizgova G., Ouzounova E., Mitov I.

Objectives: Urinary tract infection (UTI) is one of the most common reason for adults to refer to a medical specialist. Half of all men experience symptoms of prostatitis at some time in their life. The most frequently recognized causes of prostatitis are classical urinary tract pathogens rather than sexually transmitted pathogens. They are the reason for the so called acute or chronic bacterial prostatitis. According to the NIH consensus classification of prostatitis there is established category of chronic prostatitis/chronic pelvic pain syndrome (CPPS). Opinion among researchers is divided as to whether Chlamydia trachomatis, which cannot be cultured on conventional bacteriological culture media, is a causative organism of chronic prostatitis.

Our study was designed to establish the prevalence of C. trachomatis in men with chronic prostatitis and to evaluate the role of the bacterium as possible etiological agent of chronic prostatitis syndrome. From December 2005 to September 2006 a total of 236 men were enrolled in the study and evaluated for the syndrome of chronic prostatitis.

Methods: Diagnosis of chronic prostatitis was made using medical histories, physical examinations, scoring with Prostate Symptom Score Index (PSSI) and NIH Chronic Prostatitis Symptom Index (CPSI), pre-massage and post-massage test (PPMT), culture and microscopic examinations of prostatic fluids and urine. In all cases with suspicion of CPPS culture and PCR of urethral smears were performed.

Results: Based on laboratory findings 195 patients (82.6%) were diagnosed with chronic bacterial prostatitis caused by one or more of the following pathogens – Enterococus spp., S. aureus, E. coli, T. vaginalis, P. mirabilis. 41 men (17.4%) were examined for C. trachomatis infection and 5 (12.2%) of them resulted positive either on PCR and culture.

Conclusion:C. trachomatis is frequent cause for STDs in European countries. Diseases caused by C. trachomatis range from asymptomatic to those with severe sequelae. Especially in prostatitis the exact role is still under debate. The found prevalence of C. trachomatis in men with CPPS in this study resulted comparable or a little higher to that in health population. It is important to continue with the investigation including more patients for a longer period. In our opinion although the role of C. trachomatis in pathogenesis of prostatitis remains speculative, however, testing for infections is highly recommended.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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