Efficacy of gentamicin for 5 days plus doxycycline for eight weeks versus streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis
Abstract number: 1733_352
Hasanjani Roushan M.R., Soleimani Amiri M.J., Janmohammadi N., Soleimani Amiri S.
Objectives: Regimen of choice and duration of therapy in human brucellosis is unknown. The purpose of this study was to evaluate the efficacy of gentamicin for 5 days plus doxycycline for 8 weeks versus streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis
Methods: From April 2005 to October 2006, this comparative clinical study was conducted to compare the efficacy of gentamicin for 5 days plus doxycycline 100 mg twice daily for 8 weeks (regimen GD) versus streptomycin 1 gr for 2 weeks plus the same dose of doxycycline (regimen SD) for 45 days at the department of infectious diseases, in Babol, Iran. All cases were followed for 12 months after cessation of therapy.
Results: Forty-nine cases with the mean age of 34±14 years and 44 cases with the mean age of 36.5±15.3 years were treated by GD and SD regimens, respectively. The clinical manifestations and laboratory test results in these two treated groups were similar. Relapse was seen in 2 (4.1%) cases treated by regimen GD and in 2 (4.5%) cases treated by regimen SD (p > 0.05). Cure rate with regimen GD was 95.9% and with regimen SD was 95.5% (p > 0.05). Both regimens of therapy were well tolerated.
Conclusion: The result of this study shows that gentamicin for 5 days plus doxycycline for 8 weeks is as effective as standard regimen for therapy of human brucellosis.
|Session name:||European Society of Clinical Microbiology and Infectious Diseases|
|Location:||ICC, Munich, Germany|
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