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Alterations of serum lipoproteins in patients with acute brucellosis

Abstract number: 1733_311

Apostolou F., Kostoula A., Liberopoulos E., Gazi I., Spyrou A., Tsianos E., Bairaktari E., Tselepis A., Elisaf M.

Objectives: Changes in serum lipid parameters are observed during inflammation. These changes may be associated with the pathogenesis of atherosclerosis. There are no data on the possible effect of acute infection with Brucella on serum lipoproteins.

Methods: Serum lipid parameters were determined in 28 patients (18 male and 10 female, aged 52.9±14.6 years) with acute brucellosis on admission and 4 months after the initiation of appropriate treatment. Furthermore, 24 matched controls were studied. Fasting levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) AÉ, B, E and lipoprotein (a) [Lp(a)] were measured. Low-density lipoprotein (LDL) subclass analysis was performed by use of the Lipoprint LDL System.

Results: On admission, patients exhibited significantly lower levels of TC, HDL-C, LDL-C and ApoAI compared with controls, while there were no significant differences in TG, ApoB, ApoÅ and Lp(a) levels. Furthermore, mean LDL particle diameter was significantly lower in patients compared with controls. Of interest, small dense LDL-C (sdLDL-C) levels as well as the sdLDL-C/LDL-C, LDL-C/HDL-C and ApoB/ApoAI ratios were significantly higher in patients compared with controls.

Four months after treatment initiation, a significant increase in levels of TC (by 23%), HDL-C (by 37%), LDL-C (by 23%), and ApoAI (by 39%) was noticed. On the other hand, levels of TG, ApoB, ApoE and Lp(a) were not significantly altered. Furthermore, sdLDL-C levels, the sdLDL-C/LDL-C ratio, the LDL-C/HDL-C ratio and the mean LDL particle diameter were not significantly changed. However, the ApoB/ApoAI ratio was significantly decreased.

Conclusions: Significant quantitative and qualitative alterations of serum lipoproteins were seen during acute infection with Brucella. These changes were not fully restored 4 months after treatment initiation.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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