Correlation of C-reactive protein to complications and outcome during the intensive care unit course of sepsis patients

Abstract number: 1733_295

Alici O., Bavbek N., Kargili A., Kaya A., Karakurt F., Kosar A.

Purpose: Elevated concentrations of CRP have been reported to be in correlation with increased risk of death in different patient groups. There are conflicting results about the prognostic role of CRP in sepsis patients. To determine the prognostic informative value of CRP in patients admitted to the ICU with sepsis, 213 patients hospitalised in our unit were retrospectively studied.

Materials and Methods: Demographic data, comorbid diseases, all clinical, microbiological, and laboratory data were registered retrospectively. Plasma levels of CRP on days 1, 3, 5 and 7 were registered.

Results: The overall mortality rate was 37%. Nonsurvivors had significantly higher CRP levels than survivors on the 3rd day (150.8±21.9 mg/L vs 96.4±6.5 mg/L, p = 0.002). Survivors had significantly lower CRP levels on the 3rd day than the 1st day (96.4±6.5 mg/L vs 160.2±11.8 mg/L, p = 0.000) while nonsurvivors had significantly higher CRP levels on the 3rd day than the 1st day 150.8±21.9 mg/L vs 130.9±17.3 mg/L, p = 0.000). In patients with sepsis, age and diabetes mellitus were the important prognostic variables for intensive care unit mortality.

Conclusions: In sepsis, progressively increasing concentrations of CRP are correlated with increased risk of organ failure and death. Serial measurements are helpful to identify these patients who require more intensive treatment to prevent complications.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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