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Efficacy and safety of Uro-vaxom treatment for patients with recurrent cystitis: open multicentre study

Abstract number: 1733_286

Ha U-S., Chang S-G.C., Park H.K., Yoon S.J., Cho Y-H.

Objectives: To investigate the efficacy and safety of the immunotherapeutic Uro-vaxom in uncomplicated recurrent cystitis in female patients only.

Methods: Adult female patients could enroll in this multicentre, open-label study if they had acute cystitis at the enrollment visit and positive results of urine culture (≥103 CFU/mL). Patients were treated for 3 months with one capsule daily of Uro-vaxom after antibiotic therapy and observed for further 3 months. Primary efficacy criteria were cystitis recurrence rates over 6 months, distribution of cystitis and proportion of patients of cystitis.

Results: A total of 50 patients were evaluated. During the 6-month trial the number of recurrences from cystitis was significantly reduced in comparison with the 6-month pretrial period (on the average 0.64 as compared to 3.0 recurrences, p < 0.001). The case for the incidence of frequency, urgency and dysuria was remained low until the end of the trial. Uro-vaxom was well tolerated: side-effects were mentioned in 8% of the 50 patients, in the absence of case leading to treatment withdrawal.

Conclusions: Uro-vaxom significantly reduced the incidence of cystitis during the 6 months of the study including 3 months of treatment. These results demonstrate that Uro-vaxom is a valuable product for the prophylaxis of recurrent cystitis.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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