EARSS results: S. pneumoniae resistance related to serogroups?

Abstract number: 1733_246

de Kraker M.E.A., Kahlmeter G., van de Sande-Bruinsma N., Tiemersma E.W., Monen J.C.M., Grundmann H., participants EARSS

Objective: Since three years the European Antimicrobial Resistance Surveillance System (EARSS) has, next to resistance data, been collecting serotype information for S. pneumoniae isolates (SPN). We analysed the relationship between penicillin and erythromycin resistance and serotype among SPN isolates.

Methods: Since 1999, EARSS collects routine antimicrobial susceptibility test data amongst others from invasive SPN isolates. According to standard protocols, macrolide (ery) and b-lactam (pen) susceptibility are reported. Serotype data is reported according to the Danish Kauffman-Lund scheme. We chose two countries that represented a low and a high endemic situation and that reported serotype information for most SPN isolates in the database. We compared resistance rates among the most common serogroups between the high and low endemic country by chi-square test.

Results: The total number of SPN isolates with serogroup information over those tested for both antimicobial groups in 2005 was 1536/1539 for the high endemic country and 1182/1373 for the low endemic country. Pen resistance was reported 4% for the low endemic country and 12% for the high endemic country, ery resistance 11% versus 31% and dual resistance 1 versus 9%. The six most common serogroups in both countries were 1, 6, 9, 14, 19 and 23. Ery resistance was higher in the high endemic country for all six serogroups (p < 0.01), pen resistance was significantly higher for serogroups 14, 19, 23 compared to the low endemic country.

Conclusion: Irrespective of serogroup, pen and ery resistance were higher for the high endemic country. This indicates that resistance in SPN is not based on the expansion of particular clones, but rather influenced by antimicrobial consumption.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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