The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy

Abstract number: 1733_231

Niki Y., Kohno S., Aoki N., Watanabe A., Yagisawa M., Sato J., Hanaki on behalf of the JSC Surveillance Committee & The Kitasato Institute H.

Objectives: The main approach in the control of antibiotic-resistant infections is through the precise usage of specific antimicrobial agents. Comprehensive data on susceptibilities of the major pathogens to currently available agents is currently lacking. In 2006 the Japanese Society of Chemotherapy (JSC) initiated a nationwide study of major bacterial RTI pathogens (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae and Pseudomonas aeruginosa) in Japan.

Methods: A total of 924 clinical isolates from well-diagnosed adult RTI patients were obtained from 34 hospitals throughout Japan between January and April 2006. Susceptibility of these strains to 40 antimicrobial agents was tested at the central laboratory according to CLSI standards for broth microdilution method. Beta-lactamases were detected by the Nitrocefin disc method. Extended-spectrum b-lactamase (ESBL) and metallo-b-lactamase (MBL) were detected by the Cica-Beta Test (Kanto Chemical, Tokyo).

StrainNo. of strainsAntimicrobial agent% resistance
S. aureus (MRSA)205methicillin63.4*
S. pneumoniae200penicillin39a
H. influenzae165ampicillin (also b-lactamase negative)29.1
a4% resistant, 35% intermediate.

Results: See the table. One MBL-producing multi-drug resistant P. aeruginosa was found among 143 strains, and two ESBL-producing K. pneumoniae were found among 74 strains.

Conclusion: In the first nationwide surveillance of bacterial respiratory pathogens, valuable data on resistance patterns to currently available antimicrobial agents were elucidated. JSC intend to update this data annually to promote precise usage of antimicrobial agents. We also intend to extend the study to include uropathogens.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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