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Affect of length of hospitalisation on susceptibility patterns of Gram-negative bacilli isolated from intra-abdominal infections: SMART 2005

Abstract number: 1733_160

Gallagher G., Rossi F., Hsueh P.R., Báez-Villaseñor J., Wilson H.M., Abramson M.

Background: SMART (Study for Monitoring Antimicrobial Resistance Trends) is an ongoing global antimicrobial surveillance programme focused on clinical isolates from intra-abdominal infections (IAI). Isolates identified after 48 hours (h) of hospitalisation have been shown to have less susceptibility than those taken within the first 48 h. This 2005 sub-analysis assessed susceptibility patterns among Gram-negative bacilli from 5 regions of the world.

Methods: 50 major medical centres in North America, Latin America, Europe, Middle East/Africa, & Asia/Pacific tested the in vitro activity of 12 antimicrobial agents. Microdilution techniques followed CLSI guidelines. Enterobacteriaceae susceptibility rates were compared between isolates recovered <48 h & >48 h after hospitalisation.

Results: Enterobacteriaceae were recovered from 3226 pts (3422 isolates) worldwide. 648 isolates (19%) were Inducible; 2774 (81%) were non-Inducible Enterobacteriaceae. 238 inducible (7%) & 1423 (42%) non-Inducible Enterobacteriaceae were recovered <48 h after hospitalisation. The susceptibility rates are presented in the table.

thinsp;Susceptibility rate (%)
Inducible Enterobacteriaceae*Non-inducible Enterobacteriaceae#
<48 h>=48 h<48 h>=48 h  
Entrapenem96949797
Imipenem97969898
Cefepime94879381
Cefotaxime79599381
Cefoxitin27249381
Ceftazidime77579279
Ampicillin/Sulbactam34216243
Piperacillin/Tazobactam34216243
Amikacin99939795
Ciprofloxacin91838470
Levofloxacin93888672
Length of hospitalisation not reported for 6* & 33# isolates.

Conclusion: Susceptibility rates for most Enterobacteriaceae were slightly higher for isolates recovered <48 h after hospitalisation. Ertapenem, imipenem, & amikacin were the most active drugs in vitro regardless of time of hospitalisation.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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