HPV lesions in both genitalia and mouth of HIV sero-positive male patients

Abstract number: 1733_155

Giovani E., Müller R., Aguiar F., Melo J., Armonia P., Andia-Merlin R.

Objectives: HIV has become an important risk factor for HPV infection and the development of HPV associated lesions. So, the aim of this study was to correlate HPV lesions in male genitalia and in mouth of HIV sero-positive patients.

Methods: 179 male patients were selected from the Attendance Center of Special Patients with Venereal Diseases and HIV/Aids – SP/Brazil from April/03 to March/06. These patients had the HPV lesions confirmed in genitalia after clinical examination, peniscopy and biopsy performed by an Urologist. All the patients were submitted to serologic exams (HIV/Aids), and CD4 T-lymphocyte count was carried out for those sero-positives for HIV. The age, skin colour and exposure category were also analysed for all patients. The whole group was sent to a dentist for HPV lesions detection and diagnosis in oral cavity. When lesions were diagnosed, the results were confirmed by anatomy-pathological exam. After the results, the prevalence of the lesions was tabulated and a linear correlation was performed. The treatment protocol used for oral lesions was the topic administration of 75% trichloracetic acid.

Results: The mean age of the patients was 34 years, 136 (58%) leucoderm and 43 (18%) melanoderm. 46 (26%) were HIV- (32 homosexuals and 14 heterosexuals) and 133 (74%) were HIV+ (101 homo and 32 hetero). 27 patients (15%) showed concomitants lesions in genitalia and oral cavity and all they were HIV+ (20 homo and 7 hetero). 8 patients (30%) presented T-CD4 cells <200 for mm³ of blood, 15 (55%) presented 200 to 500 T-CD4, 4 (15%) presented T-CD4 > 500. All patients had total remission of the lesion after treatment, but for those that showed T-CD4 cells <200, more sessions of treatment were necessary (>4 sessions).

Conclusion: There is a positive linear correlation between HPV lesions in male genitalia and in mouth. HIV is an important risk factor for HPV infection and the development of HPV lesions in mouth.