Human immunodeficiency virus infected patients with community-acquired pneumonia: implication of respiratory viruses

Abstract number: 1733_149

Perello R., Moreno A., Cervera C., Smithson A., Miro J., Linares L., Agusti C., Camps M., Marcos M.

Background: Community acquired pneumonia (CAP), is an important source of morbidity/mortality in human immunodeficiency virus (HIV) infected patients. The aim of the present study is to evaluate the implication of respiratoty viruses (RV) in CAP in HIV-infected patients.

Methods: From June 2003 to December 2005, 67 adult HIV patients (mean age 41.39 years) with CAP were prospectively included. RV were identified by polymerase chain reaction, cellular cultures and immunofluorescence techniques from samples obtained by nasopharyngeal smears.

Results: A microbiological diagnostic was achieved in 48 patients. Forty CAPs had an isolated bacterial ethiology being S. pneumoniae the most common pathogen (85%). RV were implicated in 14 cases; in 8 as the only pathogen and in 6 in combination with bacteria's, being adenovirus plus S. pneumoniae the most frequent combination. Rhinovirus was the most common RV implicated followed by adenovirus. No statistical significant differences were found in CAP in which VR were implicated compared to CAP without presence of RV regarding: male gender (50 vs 70%; P = 0.21), mean age (40.6 vs 41 years; P = 0.92), median CD4 cell count (229.5 vs 228.5; P = 0.75), mean logarithmic viral charge (4.04 vs 3.68; P = 0.408), HAART (36 vs 41.5%; P = 0.694), positive hemoculture (21.4 vs 28.3; P = 0.85), admission in ICU (7 vs 15%; P = 0.67), mechanical ventilation (7 vs 2%; P = 0.37), APACHE II score (10.5 vs 11; P = 0.38), death (7 vs 0%; P = 0.29) and median of hospitalisation (5 vs 7 days; P = 0.076).

Conclusions: The implication of RV in CAP of HIV infected patients is not associated to a worst outcome.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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