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Frequency of proteinuria among HIV-infected patients

Abstract number: 1733_146

Ramezani A., Mohraz M., Banifazl M., Gachkar L., Yaghmaie F., Aghakhani A., Kalantar N., Nemati K., Haghighi M., Rezaie M., Velayati A.

Background: Nephropathies associated with human immunodeficiency syndrome (HIVAN) are increasingly prevalent and associated with proteinuria and rapid progression to end-stage renal failure. Some authors reported, proteinuria may be an early marker of HIVAN, and screening for its presence may be beneficial. In this study we aimed to determine the frequency of proteinuria and related risk factors in Iranian HIV positive patients.

Methods: A total of 105 HIV positive patients were enrolled in this study. All the patients filled out a questioner about demographic characteristics and their high risk behaviours. Systolic and diastolic blood pressure was examined by a physician. Patient's blood samples were tested for creatinine, albumin, hemoglobin, HCV Ab and HBs Ag. In all patients CD4 counting were done by flow cytometry. Urine samples were collected and examined for detection of proteinuria. Proteinuria was defined as ≥1 plus in urine exam on 2 consecutive dipstick urine analyses. Personal and lab data's among study groups were compared with the Chi-square using SPSS 11.5 package programme.

Results: Out of 105 HIV positive patients, 20%(n = 21) had proteinuria. Mean age of patients with proteinuria was 35.2±9.19. There was not any significant difference between patients with and without proteinuria, regarding age, sex, race, weight, risk behaviours for HIV acquisition, disease history, staging (HIV/AIDS), concurrent drug therapy (non-nucleoside reverse transcriptase inhibitors or protease inhibitors), systolic and diastolic blood pressure, hemoglobin, albumin, presence of HCV Ab and HBs Ag. Patients with proteinuria had a lower CD4 count (322.47 vs. 439.16 cells/mm3 p < 0.051) and slightly higher creatinine (1.20 vs. 0.96 mg/L p = 0.054) than those without proteinuria.

Conclusion: This study showed a relatively high prevalence (20%) of proteinuria in the HIV-seropositive population. Our study also confirmed the correlation between decreasing CD4 count and the presence of proteinuria. But it was not demonstrated an association between proteinuria and a positive hepatitis C antibody as reported in previous studies.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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