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Cysticercosis: correlation between serological and radiological diagnosis

Abstract number: 1733_40

Rodríguez Guardado A., Gómez E., Rodríguez Pérez M., Sempere A., López-Roger Roger R., Suárez Leiva P., Asensi Álvarez V., Cartón Sánchez J.A.

Objective: Human infections due to Taenia solium are common in underdeveloped countries but they are not frequent in Europe. We describe our experience in the diagnosis and management of cystecercosis in Asturias, a province in northern Spain.

Methods: We have retrospectively reviewed each patient with cisticercosis positive serological result in the Hospital Universitario Central of Asturias (HUCA), during a period of six years (2000–2006). Serum samples of each patient were tested for Taenia solium antigen, antibodies and vesicular fluid using an ELISA test. Computerised tomography or nuclear magnetic resonance were also done on all patients.

Results: We have studied ten cases. None presented significant underlying diseases. Four of them were Spanish and there were six immigrants, four from Ecuador and two from Brasil. The mean age was 45 years (range of age 34–59). Six were female. Cephalea (three cases), epilepsy and subcutaneous nodules (two cases) were the most frequent symptoms. Two patients remained asymptomatic. Eosinophilia in blood tests was not found in any of them. Faeces of each one were examined looking for parasite eggs and were negative. Nine patients presented Taenia solium antibodies, six were positive for vesicular fluid and one for Taenia solium antigen. Three patients were diagnosed of neurocistycercosis, only one of them was positive to T. solium antigen. In two cases of them the computerised tomography was negative. The nuclear magnetic resonance was positive in the three cases Two patients with neurocysticercosis were treated with albendazol during 30 days and steroids in the first seven days. One patient was treated with praziquantel three doses during one day. All the patients cured. The rest of patients received one doses of praziquantel (5 mg/kg). All patients recovered.

Conclusions: Presence of Taenia solium antibodies in serum seems to be useful for cysticercosis diagnosis. However, a positive antigen result in CSF does not seem to indicate a central nervous system infection. Nuclear magnetic resonance is more useful than computerised tomography in neurocysticercosis diagnosis. Albendazol is a very effective and safe treatment. Clinical and epidemiological results consistent with neurocysticercosis are needed in order to ask for antibody and antigen testing

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Subject:
Location: ICC, Munich, Germany
Presentation type:
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