Increased proliferation of dentate granule cells in human bacterial meningitis

Abstract number: 1732_60

Gerber J., Tauber S.C., Armbrecht I., Brück W., Nau R.

Objectives: Proliferation and differentiation of neural progenitor cells in the dentate gyrus is increased after infection in animal models of pneumococcal meningitis.

Methods: To evaluate neurogenesis in patients with acute infection of the central nervous system, brain sections of 18 patients dying from bacterial meningitis and 8 patients dying from non-neurological diseases were investigated by immunohistochemistry.

Results: In the dentate gyrus of the hippocampal formation, the density of Proliferating Cell Nuclear Antigen (PCNA)-expressing cells was higher in patients with bacterial meningitis compared to the control group (p = 0.02). Furthermore, the number of cells expressing the immature neuronal marker protein TUC-4 was increased in brain sections of persons dying from bacterial meningitis compared to control cases (p = 0.004). In the subventricular zone, no difference of cells expressing TUC-4 was observed between both groups (p = 0.39). Immature neurons expressing TUC-4 had no morphological features of apoptotic cell death and no evidence of DNA fragmentation.

Conclusion: The increased proliferation of neural progenitors suggests that endogenous mechanisms may limit consequences of neuronal destruction after meningitis. Stimulation of neurogenesis might help to improve therapy of acute inflammatory diseases of the brain.

Session Details

Date: 31/03/2007
Time: 00:00-00:00
Session name: European Society of Clinical Microbiology and Infectious Diseases
Location: ICC, Munich, Germany
Presentation type:
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