Nasal carriage and antibiotic resistance of Staphylococcus aureus in HIV-infected patients
Abstract number: r2176
Kakabadze T., Tsertsvadze T., Macharashvili N., Dolmazashvili E.
To evaluate the rate and risk factors of nasal S. aureus carriage in asymptomatic HIV patients; to assess antibiotic resistance of yielded S. aureus strains.
In this prospective case controlled study anterior nares swabs/cultures were obtained from 91 asymptomatic adult HIV patients attending out-patient department of AIDS and immunodeficiency of Tbilisi, Georgia and 60 HIV negative persons. Antibiotic resistance was testing by using disk-diffusion method. To determine the susceptibility to methicillin, oxacillin was used as a marker. HIV patients undergo investigation about their past medical history and behaviour.
A total 39 swabs (42.8%) yielded S. aureus from HIV positive patients and 14 swabs (23.3%) from HIV negative persons. Antimicrobial resistance was determined for isolates from HIV positive patients. Yielded S. aureus strains were resistant to: clindamicin in 30.7% of cases, chloramphenicol 41%, oxacyllin 53.8%, amoxicillin-clavulan acid- 64.1%, ampicillin 97.4%, penicillin G 100%, ciprofloxacin 23.08%, trimetoprim 48.7%, erythromycin 41.02%, amycacin 28.2%, tetracycline 46.15%. All isolated S. aureus strains were susceptible to vancomycin.
High rate of S. aureus carriage was detected in studied HIV population. The S. aureus carriage was not correlated to CD4+ T-cell count or granulocytopenia, but was influenced by previous hospitalisation, skin infection, antibiotic use and IDU practice. High rate of antimicrobial resistance may be related to uncontrolled use of cheaper oral antibiotics in Georgia. The prevalence of methicillin (oxacyllin) and ciprofloxacin resistant S. aureus colonization was higher in HIV infected then in general population of Georgia.
|Session name:||XXIst ISTH Congress|
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