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Disseminated infection due to Candida guilliermondii in a patient with acute myelogenous leukaemia. A case study

Abstract number: r2154

Panzaru  C., Dan  M., Burcoveanu  C., Mereuta  A.

Objective: 

To evaluate the origin of candidaemia in a patient with acute myeloid leukaemia

Methods: 

We used biphasic media (Haemoline Performance Duo: bioMerieux-France) for blood cultures. Isolates were identified using ID 32C (API yeast identification system, bioMerieux) and susceptibility tests were performed with ATB FUNGUS (bioMerieux). The strains were considered clinically significant based on standard definitions established by the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections (2002).

Results: 

A 43-years-old patient admitted with acute myeloid leukaemia, developed bronchopneumonia and sepsis during profound neutropenia. Fever and pulmonary infiltrates did not improve by using empiric antibacterial therapy (cefoperazone-sulbactam, sulphametoxazol-trimethoprim). Blood and sputum cultures were performed and the patient received voriconazole. Both cultures, from blood and sputum, yielded Candida guilliermondii after 48 hours of incubation. The isolates had the same biochemical and antimicrobial spectrum, and were susceptible to amphotericin B and fluconazole. After a few days of therapy with voriconazole, fever disappeared and the clinical state of patient improved. A culture from pharyngeal swab, performed after 11 days, yielded the same microorganism.

Conclusion: 

1. The emergence of less common but medically important fungal pathogens, including Candida guilliermondii, contributes to the rate of morbidity and mortality, especially in the increasingly expanding population of immunocompromised patients. 2. We consider that the oropharyngeal colonization with Candida guilliermondii and profound neutropenia predisposed our patient to develop bronchopneumonia and candidaemia.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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