Review of infections due to Pseudallescheria boydii

Abstract number: r2101

Horre  R., Schnitzler  N., Grueger  T., de  S., Hoog  J., Guarro  

Infections due to Pseudallescheria boydii (Scedosporium apiospermum) are known already since 1899. An analysis of 528 published cases in humans was performed to reveal the spectrum of disease, risk factors, geographic distribution and outcome of infection. Initially the fungus was observed mainly as a cause of mycetoma in temperate climate zones after traumatic inoculation. Since the seventies of the previous century, other disease entities have become preponderant. Particularly pulmonary infections in immunocompromised patient became relatively frequent, so that the species can be viewed as a truly emerging fungus in the growing hospitalised population with severe immune disorders. However, two disease entities are noted in patient populations without apparent changes in frequency. The species regularly colonises lungs of patients with cystic fibrosis, but thus far escaped attention because its presence was concealed by co-occurring Aspergillus fumigatus. Another, unique syndrome is delayed cerebral infection after near-drowning. Since it is unlikely that the frequency of P. boydii in surface waters, lakes and ditches has increased dramatically since 1970, we have to assume that also this clinical picture has long been misdiagnosed. Given the low susceptibility of the fungus against current antifungals, development of proper diagnostics for P. boydii is highly significant.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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