Worldwide antimicrobial susceptibility patterns of inducible Enterobacteriaceae isolated from intraabdominal infections: results from SMART 2004

Abstract number: p1806

Baquero  F., Hsueh  P-R., Paterson  D.L., Rossi  F., Satishchandran  V., Snyder  T., Rawlins  S., Gallagher  G., Abramson  M.A., DiNubile  M.J., Chow  J.W.

Objective: 

SMART (Study for Monitoring Antimicrobial Resistance Trends) is an ongoing global antimicrobial surveillance program focused on clinical isolates from intraabdominal infections (IAI). The aim of this analysis was to assess antimicrobial susceptibility patterns among inducible Enterobacteriaceae from 5 different regions of the world during 2004.

Methods: 

81 centres in North America (NA), Latin America (LA), Europe (EU), Middle/East/Africa (ME/A), & Asia-Pacific (A/P) tested the in vitro activity of 12 antimicrobial agents commonly used to treat IAI against consecutive unique aerobic and facultative Gram-negative bacilli using microdilution techniques according to CLSI guidelines. All Enterobacter, Serratia, Citrobacter, Providencia spp., Morganella morganii, Hafnia alvei, & Proteus vulgaris were considered to have inducible beta-lactamases for the purposes of this study.

Results: 

Inducible Enterobacteriaceae were recovered from 1075 of the 5569 patients (19%) in the study worldwide, constituting 1104/6156 (18%) of the total isolates. 359 (33%) of the inducible Enterobacteriaceae isolates were recovered within 48 hours of hospitalization. Enterobacter spp. (49%), Citrobacter spp. (23%), M. morganii (10%) & Serratia spp. (10%), were the most commonly isolated inducible Enterobacteriaceae. The % susceptible isolates are reported below by region:

Conclusion: 

Among inducible Enterobacteriaceae causing IAI in this study, carbapenems were the most reliably active drugs in vitro across regions.