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Decrease of antibiotic resistance of group A streptococci in Korea

Abstract number: p1803

Kim  S., Koh  E.-H., Bae  I.-G., Lee  N.Y.

Objectives: 

The antibiotic resistance and its mechanism of group A streptococci (GAS) varies according to nations or study period. We have investigated antibiotic resistance and mechanism of macrolide resistance for the strains isolated from Korean children and compared to the previous (2002) results.

Methods: 

Throat cultures were taken from 2351 elementary school children in Jinju, Korea from October to December, 2004 to isolate GAS. Antibiotic susceptibility test to erythromycin (EM), clindamycin (CC), and tetracycline (TC) was performed by disk diffusion method. Macrolide resistance phenotype and genotype as well as emm genotype were studied.

Results: 

Isolation rate of GAS was 14.0% (328/2351). Resistance rates of EM, CC, and TC were 9.8%, 8.8%, and 18.3% respectively, which were dramatically decreased from 51%, 34%, and 30% in 2002 at the same area. Emm44/61 was prevalent (29%), while emm12 was the most common type (34%) in 2002. cMLSB, M, and iMLSB were observed in 87.5%, 9.4%, and 3.1% respectively, compared to 64%, 34%, and 2% in 2002. The strains with cMLSB and iMLSB had ermB gene and the ones with M phenotype were positive with mefA gene.

Conclusion: 

The resistance rates to EM and CC were dramatically decreased compared to the past (2002). Education to the public and physicians, decreased consumption of antibiotics, acquisition of immunity to the resistant strains, or change of prevalent emm types could be considered to explain the reason of decrease of antibiotic resistance. Although antibiotic resistance rate was decreased, cMLSB type which has high MIC was prevalent suggesting treatment failure for those children carrying these resistant strains in Jinju, Korea.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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