Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal carriage and invasive Staphylococcus aureus strains
Abstract number: p1696
Sabat A., Melles D., Martirosian G., Grundmann H., van Belkum A., Hryniewicz W.
This study was designed to examine the distribution of the sdr genes among nasal carriage and invasive Staphylococcus aureus strains as well as methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S aureus (MRSA).
The presence or absence of the sdr genes using DNA from 497 S. aureus strains was determined by a novel triplex PCR procedure. The two-tailed Fisher's exact test was used to analyse the distribution of the sdr genes among S. aureus strains originating from different hosts. P values less than 0.05 were considered a statistically significant difference.
The sdr locus was found in all 497 investigated S. aureus strains although in 29 strains it contained only the sdrC gene (sdrD sdrE). The sdrC + sdrD sdrE gene profile was exclusive to MSSA strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and MRSA strains (P < 0.0001).
Our findings suggest that MSSA strains with the newly uncovered sdrC + sdrD sdrE gene profile have a substantially decreased potential to establish bone infection.
|Session name:||XXIst ISTH Congress|
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