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Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal carriage and invasive Staphylococcus aureus strains

Abstract number: p1696

Sabat  A., Melles  D., Martirosian  G., Grundmann  H., van Belkum  A., Hryniewicz  W.

Objectives: 

This study was designed to examine the distribution of the sdr genes among nasal carriage and invasive Staphylococcus aureus strains as well as methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S aureus (MRSA).

Methods: 

The presence or absence of the sdr genes using DNA from 497 S. aureus strains was determined by a novel triplex PCR procedure. The two-tailed Fisher's exact test was used to analyse the distribution of the sdr genes among S. aureus strains originating from different hosts. P values less than 0.05 were considered a statistically significant difference.

Results: 

The sdr locus was found in all 497 investigated S. aureus strains although in 29 strains it contained only the sdrC gene (sdrD – sdrE–). The sdrC + sdrD – sdrE– gene profile was exclusive to MSSA strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and MRSA strains (P < 0.0001).

Conclusion: 

Our findings suggest that MSSA strains with the newly uncovered sdrC + sdrD – sdrE– gene profile have a substantially decreased potential to establish bone infection.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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