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Dengue virus infections in children and adolescents

Abstract number: p1667

Larrú Martínez  B., Quiroz  E., Castrejón  M., deWong  E., Castaño Guerra  J., Nieto  O., SaldanadeSuman  D., Estripeaut Calderon  X., Sáez-Llorens  

Objectives: 

Study the prevalence of dengue virus infection on children in Panama and describe their clinical features.

Methods: 

We reviewed all the reports of dengue virus infection from January 2000 to August 2005. Epidemiological and clinical dates were recorded. Diagnosis was made with positive IgM antibody test or increase in serum IgG, 5 days after onset of symptoms or culture of the virus in the first fifth days of illness.

Results: 

457 children were included in our study. Distribution according sex was: 57.6% female and 42.4% male. Median of age was 13 years (IQR = 6). During the follow-up study we recorded 2 years when the number of cases increased. The distribution of cases among the study was: 8.4% in 2000, 33.9% in 2001, 20.9% in 2002, 6.6% in 2003, 7.0% in 2004 and 23.1% in 2005. The proportion of paediatric patients also varied from; 11.9% in 2000, 9.6% in 2001, 12.4% in 2002, 9.7% in 003, 7.8% in 2004 and 4.4% in 2005. In Panama City we recorded 65.3% of the infants. We detected an increase in the number of patients in the rain season, from May till November. The mean of days between the onset of symptoms and the first blood sample was 6.3 days (DS: 6.7) A second sample was obtained in 23.6% of our infants with an average time of 10.1 days (DS: 7.4). The frequency of classical symptoms related to dengue virus infection was: fever (95.2%), severe headache (74.2%), chill (65.9%) rash (63.5%), myalgia (51.9%), retro-orbital pain (51.6%), arthralgia (43.3%), gastrointestinal symptoms (37.4%), inflamed pharynx (26.7%), cough (26.5%), mild respiratory symptoms (18.6%) and diarrhoea (10.7%). In our infants the symptoms which were detected first were; fever, severe headache, chill, myalgia, retro-orbital pain, arthralgia, mild respiratory symptoms, cough and inflamed pharynx. We did not observed differences on clinical features between girls and boys. However, we detected detected significative differences among symptoms when we compared infants who were <=5 years old with those who were older (p < 0.005). Four of our patients died because of dengue hemorrhagic fever.

Conclusion: 

Dengue is endemic in Panama as in most tropical countries and is one of the world´s major emerging infectious disease. More data about this illness are needed to elaborate sanitary programmes which contribute to control this infection.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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