Adjustment of antibiotic treatment according to the results of blood cultures leads to decreased antibiotic use and costs
Abstract number: p1461
Berild D., Mohseni A., Diep L.M., Jensenius M., Ringertz S.H.
To investigate whether the results of blood cultures led to changes in antibiotic use and costs in a university hospital in Norway
Medical records from all patients with positive blood cultures in 2001 were analysed retrospectively. Factors predisposing to infections, results of blood cultures, antibiotic use, and outcome were recorded.
The antibiotic use in 226 episodes of true bacteraemia were analysed. According to guidelines empirical antibiotic treatment should be adjusted in 166 episodes. Antibiotic use was adjusted in 146 (88%) of these 166 episodes, which led to a narrowing of therapy in 118 (80%) episodes. Compared to empirical therapy there was a 22% reduction in the number of antibiotics. Adjustment of therapy was more often performed in Gram-negative bacteraemia and polymicrobial cultures than in Gram-positive bacteraemia. In bacteraemia caused by ampicillin-resistant E. coli, ampicillin was mostly replaced by ciprofloxacin. The cost for 7 days adjusted therapy was 19800 EUR (23%) less than for 7 days of empirical therapy.
Adjustment of antibiotic use according to results of blood cultures led to improvement of antibiotic use and decreased costs.
|Session name:||XXIst ISTH Congress|
|Back to top|