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Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20-year study in a large French teaching hospital, 1983–2002

Abstract number: p1458

Robert  J., Bismuth  R., Jarlier  V.

Objective: 

To assess the evolution of glycopeptides' susceptibility in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in a large French teaching hospital from 1983 to 2002.

Method: 

Determination of glycopeptides' MICs by using the E-test method in Mueller-Hinton agar on a sample of randomly selected MRSA strains.

Results: 

A total of 1445 MRSA were tested, and one vancomycin-intermediate MRSA (VISA) and 31 teicoplanin-intermediate MRSA (TISA) strains were detected. The first strains were detected in 1985, and all strains were gentamicin-resistant (GR). None of the gentamicin-susceptible strains has a glycopeptide MIC> 3 mg/L. In addition, there was a significant increase in glycopeptides' MIC geometric means over the years, and this increase was higher for teicoplanin than for vancomycin.

Conclusion: 

The higher increase in teicoplanin MICs and the good correlation between both glycopeptides' MICs, suggests systematic determination of teicoplanin MIC to screen for abnormal glycopeptide susceptibility between GR-MRSA.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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