Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20-year study in a large French teaching hospital, 1983–2002

Abstract number: p1458

Robert  J., Bismuth  R., Jarlier  V.


To assess the evolution of glycopeptides' susceptibility in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in a large French teaching hospital from 1983 to 2002.


Determination of glycopeptides' MICs by using the E-test method in Mueller-Hinton agar on a sample of randomly selected MRSA strains.


A total of 1445 MRSA were tested, and one vancomycin-intermediate MRSA (VISA) and 31 teicoplanin-intermediate MRSA (TISA) strains were detected. The first strains were detected in 1985, and all strains were gentamicin-resistant (GR). None of the gentamicin-susceptible strains has a glycopeptide MIC> 3 mg/L. In addition, there was a significant increase in glycopeptides' MIC geometric means over the years, and this increase was higher for teicoplanin than for vancomycin.


The higher increase in teicoplanin MICs and the good correlation between both glycopeptides' MICs, suggests systematic determination of teicoplanin MIC to screen for abnormal glycopeptide susceptibility between GR-MRSA.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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