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Risk factors for polymyxin-only susceptible Pseudomonas aeruginosa bacteraemia

Abstract number: p1356

Koletsi  P., Kopterides  P., Michalopoulos  A., Mastora  Z., Rellos  K., Falagas  M.

Objectives: 

To identify risk factors associated with the development of polymyxin-only susceptible (POS) P. aeruginosa bacteraemia.

Methods: 

Case-control study performed in a tertiary-care hospital in Athens, Greece (01/2002-08/2005).

Results: 

Our study population consisted of 56 patients with P. aeruginosa bacteremia. In 16 of these patients (28.6%) the isolate was susceptible only to polymyxins (POS group) and in 40 (71.4%) the isolate remained sensitive to carbapenemes (non-POS group). Mortality was 62.5 % and 37.5% for the POS and non-POS group, respectively (p = 0.09). Bivariable analysis showed that exposure to carbapenems (p = 0.001), quinolones (p = 0.043), metronidazole (p = 0.035), and glycopeptides (p = 0.018) as well as admission to the intensive care unit (ICU) (p = 0.023), tracheotomy (p = 0.035), steroid treatment (p = 0.008) and parenteral feeding (p = 0.008) were associated with isolation of a POS strain among patients with P. aeruginosa bacteremia. The multivariable analysis showed that only prior use of carbapenem was an independent risk factor (OR, 9.0; 95% CI, 2.4–34.3; p = 0.001) for development of POS P. aeruginosa bacteremia.

Conclusion: 

The results of this study provide insight into the rising problem of POS P. aeruginosa bacteremia by showing that is associated with a high mortality and highlighting that prior carbapenem use as an independent risk factor for its development.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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