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Determinants of human papilloma virus infections in HIV-infected women

Abstract number: p1064

Ribeiro-Ayeh  S., Labeith  D., Frank  U.

Objective: 

To investigate the correlation between cervical dysplasia and socio-demographic and immunologic determinants in HIV positive women.

Methods: 

Women admitted to a University Hospital as in-patients during the 5-year study period were included in the study. Data were abstracted from clinical charts. Individuals were divided into two groups, those with normal (Pap I-II) and abnormal (Pap III-IV) cervical cytological screening results. Statistical methods were used to compare socio-demographic and clinical variables. Analysis was performed using Statistical Package for Social Sciences (SPSS).

Results: 

A cohort of 75 women who had tested positive for human immunodeficiency virus (HIV) was included in the study. The mean age was 33.9 (range 19–56). Fifty-one individuals (68.0%) originated from Europe, 16 (21.3%) from Africa and eight (10.7%) from Asia. The overall prevalence of abnormal cytological smears was 29.5%. During the study period, 41 (54.7%) presented with normal and 34 (45.3%) with abnormal smears. Of these 34 women, 27 (79.4%) had cytological evidence of human papilloma virus infection (HPV). Herpes simplex virus infection was detected in seven (9.3%) women, Trichomonas vaginalis and Chlamydia in five (6.7%) and seven (9.3%), respectively. When comparing both groups, no significant association was found between socio-demographic determinants and the presence of dysplasia. However, a significant determinant for HPV infection was immunosuppression (CD 4 cell count 291 vs 488/ml; viral load 134.679 vs 16.102 RNA copies/ml). Numbers of cytological changes due to HPV infections occurred more frequently in this group (cytological evidence of infection 79.4 vs 24.4%; Condylomata acuminata 29.4 vs 7.3%).

Conclusions: 

Cervical dysplasia due HPV infections appears to be highly correlated with the immunosupression in HIV positive women.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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