Pneumonia risk factors in patients with febrile neutropenia
Abstract number: p693
Aguilar-Guisado M., Cordero E., Cisneros J.M., Espigado I., Noguer M., Parody R., Pachón J.
To analyse risk factors of pneumonia in patients with cancer and febrile neutropenia.
Prospective study of all patients with cancer and febrile neutropenia admitted in Oncology or Hematology Departments. Study period: from November 2002 to February 2005. Analysed variables: demographics, kind of cancer, stage and therapy for cancer, another inmunosuppresive factor, previous antimicrobial therapy. Univariate and multivariate analysis of risk factors for pneumonia.
Three hundred forty seven cases of febrile neutropenia were included, of which 61 had a pneumonia. Median age was 43.2 years, and 36 (59%) were males. Fifty three (87%) were patients with haematological malignancies, and 14 (23%) were blood stem-cell transplantation recipients. Risk factors for pneumonia in multivariate analysis were: previous steroid therapy (RR 2; IC95%: 1.13.6) and induction/consolidation chemotherapy for cancer (RR 2.3; IC95%: 1.15.3). In patients with haematological malignancies risk factors in multivariate analysis were previous steroid therapy (RR 2.4; IC95%: 1.15.5) and induction/consolidation chemotherapy for cancer (RR 2; IC95%: 1.13.6); In patients with solid cancer risk factors in multivariate analysis were previous antimicrobial therapy (RR 11.5; IC95%: 273). In patients in induction/consolidation chemotherapy for cancer, the only risk factor selected by multivariate analysis was previous therapy with quinolones (RR 2.4; 1.15.6).
Independent risk factors for pneumonia in patients with febrile neutropenia and haematological malignancies are previous steroid therapy and induction/consolidation chemotherapy for cancer. In patients with solid cancer, the only independent risk factor is previous antimicrobial therapy. In patients in induction/consolidation chemotherapy for cancer, it is previous quinolones therapy.
|Session name:||XXIst ISTH Congress|
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