Nocardiosis: a retrospective study of 41 French cases

Abstract number: p690

Laurent  F., Pangon  B., Sanchez  R., Boiron  P.

A retrospective study of Nocardia infections was achieved among 109 French regional hospitals. In the period from 2000 to 2003, 41 cases were collected and analysed on the basis of a closed detailed questionnaire. Molecular identification showed that 44% of strains were N. asteroides complex, 27% were N. farcinica, 15% were N. nova, 9% were N. brasiliensis, and 5% were N. otitidiscaviarum. The most common factor that predisposed individuals to nocardial infection was therapy by steroids (24%), followed by cancer (19%), COPD (14%), AIDS (12%), or solid organ transplantation (7%). No predisposing factor was observed for 24% of the patients. Nocardiosis occurred more commonly in the second part of the life, with 70% of the patients between the ages of 50 and 90 years of age. The sex ratio was 1.4. The most common clinical form was pulmonary disease (51%), followed by cutaneous (41%), and cerebral disease (17%). Bacteria were found on direct smear in 65% of the patients and in pure culture in 73% of the samples. After treatment, among the valuable patients (n = 28), 82% were cured and 7% showed a recurrence and 11% died with a mortality directly attributed to nocardiosis.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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