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Different HIV 1-subtypes and diseases observed in a group of immigrants hospitalised between 2001–2005

Abstract number: p614

Valencia  M.E., Holguin  A., Alvarez  A., Moreno  V., Lago  M., González Lahoz  J.

Objectives: 

To analyze the origin countries, the diagnosed diseases, the immuno-virological characteristics and the HIV-subtypes in 78 seropositive individuals

Patients and methods: 

We developed a data base for analysing a group of 78 HIV + immigrants attended as in-patients during the last 5 years (2001–2005). HIV subtyping was performed by phylogenetic analysis of the proteasa and retrotranscriptase genes in 55 (70%) plasma specimens. Statistical study was done by SPSS 11.0.

Results: 

Nationality could be evaluated in 72 subjects: Forty one (57%) were from sub-Saharian Africa (30 Equatorial Guinea, 6 Nigeria, 3 Camerun), 19 (26.4%) from South America (7 Ecuador, 3 Brasil, 3 Peru, 3 Colombia), 8 (11.1%) from another European countries, 2 from Asia and 2 from Marocco. Forty (51.3%) had been infected by heterosexual contact and HIV was diagnosed at the hospitalisation time in 35 cases (45%). More frequent diagnosed diseases were tuberculosis in 16 subjects (20.5%), candidiasis in 19 (24.4%), pneumonia in 15 (24.4%) and malaria in 17 (21.8%). Positive antibodies to hepatitis C virus (HCV) was detected in 12 patients (15.4%), to hepatitis B virus (HBV) in 5 (6.4%) and 6 had active syphilis (7.7%). Mean CD4+ cells was 261 cells per mm3 (r: 3–1176) and mean viral load was 118000 copies/ml (r: 50–500000). Subtype B was recognized in 26 patients and none of them was African. HIV-1 subtypes and recombinants were recognized in 29 (53%) out of the 55 subtyped specimens: 2A, 2C, 2D, 16G, 5GA, 1JG and 1GK recombinants.Therefore, clade G and AG recombinants were the most frquent variants (55,2% and 17,2% respectively). Moreover, intersubtype recombinants at the pol gene appeared in 24% of cases carrying non-B subtypes. All non-B strains infected Africans but in contrast, South Americans and Europeans carried uniformly subtype-B variants. There was not relationship between HIV-subtype and clinical manifestations.

Conclusions: 

A relatively high proportion of HIV-1 non-B variants, mostly carrying clade G sequences, caused HIV-1 infection in the studied population. Regardless the subtype, a great number of subjects had acquired HIV infection through heterosexual contacts, did not know the HIV infection, had an elevated viral load and developed seriously illness. Epidemiological implications, plasma viremia quantification, susceptibility to antiretroviral drugs and clinical implications of the presence of those variants in this collective need to be further studied.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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