Secondary acute viral hepatitis

Abstract number: 1135_262

Cambrea C.S., Rugina S., Ilie M., Rugina C.N.

Introduction:  

There are some diseases caused by viruses that secondary affect liver. These viruses are: Epstein Barr, Cytomegaloviruses, adenoviruses, Echo, Coxsachie, herpes simplex, varicella zoster, and rubella virus.

Objective:  

To evaluate the clinical and biological evolution of some secondary acute hepatitis.

Material and method:  

Study about 53 patients hospitalized with secondary acute viral hepatitis in Children Infectious Diseases Department of Clinical Infectious Diseases Hospital of Constanta during a period of one year (2003). The etiological diagnosis was established on clinical and paraclinical data (serological markers – ELISA method). In order to establish a complete diagnosis we checked the following syndromes: cytolitic, hepatoprive and billiary retention. Also we studied parameters such as age, sex, residence and period of hospitalization.

Results:  

From the total of 53 patients the most of the cases with secondary acute viral hepatitis were patients with infectious mononucleosis – 25 cases, followed by patients with rubella – 17 cases, by patients with cytomegalovirus infections – 9 cases, and by varicella zoster– 2 cases. Patient's age was between 2 and 17 years. Sex ratio shown a predominant feminine injury (M:F = 1:2.53). For residence point of view the majority of children were from urban area (31 patients from 53). The cytolysis syndrome was presented with a slight elevation of ALT (2–5 N) in majority of cases (except one case with infection with a severe form of hepatitis), such as billiary retention syndrome. The hepatoprive syndrome was light and medium in all cases except the patient already mentioned with varicella zoster infection in an immunodepressed person. There were no colestatic forms and no chronically cases or deceases.

Conclusions:  

The secondary acute viral hepatitis presented a favorable evolution in almost all our cases. In the context of some viral diseases hepatic injury is frequent but slight, sometimes asymptomatic. In these diseases generally the liver affection is underestimated in our area.