Fever of unknown origin and ferritin level: three cases of adult-onset Still's disease

Abstract number: 1135_175

Avkan Oguz V., Yapar N., Alp Cavus S., Eren O., Kuruuzum Z., Cakir N., Yuce A.

Background:  

Fever of unknown origin (FUO) is a clinical picture which has both infectious and noninfectious causes. Neoplasm and connective tissue diseases are most common noninfectious etiological categories. Among connective tissue diseases, Adult-onset Still's disease (ASD) accounts for approximately one quarter of cases. Clinical and laboratory findings are nonspecific in ASD and serum ferritin levels were markedly elevated.

Purpose:  

In this study, we presented three cases of FUO diagnosed as ASD with different clinical and laboratory findings whereas ferritin levels markedly elevated in all patients.

Cases:  

Cases presented here were 23, 25 and 20 years old male patients. Clinical and laboratory findings were summarized in the table.

Conclusion:  

As shown in the table clinical and laboratory findings of all patients were different and nonspecific. Long lasting fever, arthralgia with elevated levels of CRP, ESR, and ferritin were common findings. Most published studies focused on the potential usefulness of serum ferritin assay for diagnosing ASD. In FUO cases, after exclusion of infections and malignancies, diagnosis of ASD was supported with the elevation of serum ferritin levels strongly.