Antibody titre to hepatitis B vaccine after 5 years of vaccination in Iranian children

Abstract number: 1135_133

Salehi H.

Background:  

The first dose of hepatitis B vaccine in first year of life induces immunity about 85–95% and level of antibady(Ab) decreases subsequently. The need to assece the boster dose of Hepatitis B vaccine is the main purpose of this study.

Materials and methods:  

4160 children aged 6 years from three province of IRAN whom were vaccinated at birth, 1.5 and 9 months by recombinant hepatitis B vaccine were selected randomly and a questionnaire were filled for weight at birth, growth condition, chronic diseases and any medication and tested for antibody titre to Hepatitis B surface antigen. The level of Ab under 10 MIU/ML were assumed negative.

Result:  

2609(65%) of subjects were boy and 1481(35%) girls. From 4160 children, 1248(30%) were negative for hepatitis B Ab. 1017(39%) of boys and 473(32%) of girls were seronegative(non-immune).

Conclusions:  

Our study suggests that high percentage (30%) of vaccinated children are non-immune after 5 years and need the revaccination.