Antibiotic susceptibility patterns and serotypes of Streptococcus pneumoniae isolated from invasive and other infections at a university hospital in Turkey

Abstract number: 1135_108

Yaman A., Kibar F., Gürler N., Büyükçelik Ö., Dündar  I.H.

Objectives:  

To determine the antibiotic susceptibility and serotype prevalence of clinically significant S. pneumoniae isolated from a teaching hospital in Turkey.

Methods:  

The antimicrobial susceptibilities to nine antimicrobial agents of 61 clinical isolates of Streptococcus pneumoniae recovered from patients with invasive and other clinically significant pneumococcal infections from 2002 to 2004 were studied using E-test and disk diffusion methods following the NCCLS guidelines. Of the 61 isolates, 25% (n = 15) were from blood, 20% (n = 12) from bronchoalveolar-lavage, 16% (n = 10) from tracheal aspirate, 10% (n = 6) from cerebrospinal fluid, 8% (n = 5) from pleural fluid, 7% (n = 4) from endophthalmitis, 5% (n = 3) from peritoneal fluid, 3% (n = 2) from sinus aspirate, 3% (n = 2) from middle ear fluid, 2% (n = 1) from catheter, 2% (n = 1) from fistula specimen. Serogrouping of the pneumococcal isolates was performed using the Quellung technique (Statens Serum institute, Copenhagen, Denmark).

Results:  

Antibiotic susceptibilities and serotypes were shown in Table. Capsular types of 46 pneumococcal isolates belonged to types 23 (24%), 19(15%), 9(15%), 6(13%), 18(11%), 7(11%), 1(7%) and 3(4%).

Antibiotic susceptibilities of 61 isolates of S. pneumoniae

Conclusions:  

Antibiotic resistance was common in pneumococcal isolates in our region. Vaccine formulations can prevent the majority of pneumococcal infections.