Predictors of outcome in patients with blood-stream infections

Abstract number: 1135_107

Ayaz C., Celen M.K., Geyik M.F., Hosoglu S., Ulug M.

Objective:  

To evaluate the epidemiology and risk factors of bloodstream infections (BSI), to determine the mortality associated BSIs and identify independent predictors of mortality.

Methods:  

This study was performed retrospectively, at the hospital from April 2002 to November 2002.

Results:  

324 patients with BSI were enrolled to the study. Mean age was 41.7 ± 23.1 years old, and 196 (60.5%) were male. During study period 407 episodes occurred, of which 47.4% were nosocomial bacteraemia, 25.8% were community acquired bacteraemia, 22.2% represented contamination and 4.6% represented transient bacteraemia. Gram positive microorganisms were the most commonly isolated microorganisms (66.5%). Nosocomial BSI occurred in 134 (41.3%) patients. The most common pathogens nosocomial BSI group were coagulase negative Staphylococcus (29.2%), S. aureus (23.5%), E. coli (11.9%), Acinetobacter spp. (6.4%), P. aeruginosa (5.6%) and Klebsiella spp. (5.1%). Methicillin resistance was detected in 58% of staphylococcus isolates in nosocomial BSI group. 18.7% of the patients died. Mortality rate associated with bacteraemia obtained as 14.8%. Mortality rate in nosocomial BSI group obtained as 33.4%. Multivariate analysis revealed nosocomial acquisition, age > 60 years, hospital stay more then 7 days, stay in intensive care unit as factors associated with mortality rate.

Conclusion:  

These results indicate that eliminate factors influencing the outcome of bacteraemia especially in nosocomial bacteraemia. The prevention of nosocomial infections and appropriate antibiotic treatment can improve the prognosis of patients.