Epidemiology of Helicobacter pylori infection in Kashan

Abstract number: 1135_7

Sharifi H., Moniri R., Mehrzad V., Mousavi G.A., Ehteram H., Ahmadi H.

Objectives:  

Role of Helicobacter pylori (HP) in many gastrointestinal disorders such as peptic ulcer , gastritis, intestinal metaplasia and stomach cancer is established. In order to determine risk factors of its infection this study was done.

Methods:  

Two hundred and thirty-two patients with gastrointestinal signs were studied. Endoscopy was done by internist and 2–3 biopsies from antrum was taken. Specimens were processed by Shandon tissue Processor (Citadel). Prepared slides were stained by Hematoxycillin and Eosin & also giemsa. Two pathologists and one microbiologist studied the slides. Patients, blood groups were determined. Patients, data including age, sex, smoking, residential status, clinical signs, pathologic diagnosis, blood group were recorded and then analysed.

Results:  

Of 232 patients 130 (56%) were females and 102 (44%) were males. 222 patients (124 women and 96 men) showed HP infection . Frequency of infection in females was 95.4% and in males 94%. 88 patients (38%) were in age group <=30 and 144 (62%) in age group 31–80 years. HP was detected in 84 (95.4%) in first group and 136 (94.4% ) in second, group. 95.7% rural and 41.8% urban showed HP infection. The most frequent blood group was B (78%). All smoked patients and patients with history of smoking showed infection. HP infection in active gastritis was 98.3% and inactive gastritis with intestinal metaplasia was 64.2%. The most common symptom was epigastric pain and the least common was hiccup and vomiting.

Conclusions:  

Frequency of HP infection is high (95.7%). No relation is between age , sex, clinical signs and HP infection. Persons with blood group B are more predipose to HP and smokers are high risk for HP infection. No difference is between urban and rural.