A comparative in vitro analysis of amoxicillin-clavulanic acid and seven comparative agents in 15,521 paediatric respiratory isolates

Abstract number: 1134_03_210

Bouchillon S., Johnson J., Hoban D., Butler D., Min S., Miller L., Payne D.

Background:  

Several large scale adult surveillance studies have demonstrated the ongoing effectiveness of amoxicillin-clavulanic acid (A/C) even after 20 years of clinical use. This is a retrospective collection of data comprising over 15,000 paediatric respiratory isolates collected from several surveillance studies conducted in 54 countries over a period of 5 years. The in vitro activity of A/C and 7 comparators are reported for S. pneumoniae (SPN), H. influenzae (HFLU), M. catarrhalis (MCAT) and S. pyogenes (SPY). Not all antimicrobials were tested in all studies, or against all isolates.

Methods:  

Regional reference laboratories used broth microdilution technique according to NCCLS guidelines.

Results:  

A/C at the Augmentin ES-600 PK/PD breakpoint of 4 mcg/mL for SPN, was the most active agent tested with 96.5% susceptible including 83.5% and 88.6% susceptible for PRSP and ERSP, respectively.

Conclusions:  

A/C activity was comparable to or better than comparator agents against all the key respiratory pathogens including resistant strains involved in paediatric respiratory infections.