Occurrence of resistance to wide spectrum of antimicrobial agents in clinical isolates of the genus Acinetobacter
Abstract number: 1134_03_205
Sodomova E., Michalkova-Papajova D., Vrabelova-Poczova M., Rovna D., Kettner M.
The aim of the study was to determine the occurrence of resistance to 33 antimicrobial agents in Acinetobacter clinical isolates.
Clinical isolates included in the study originated from Hospital Ruzinov, Bratislava (Slovakia). The majority of 37 isolates tested were obtained from Burn Department (35.1 %) and from Surgical Department (29.7 %) of this hospital and were isolated from burn infections (29.7 %) and wounds (27.0 %). The isolates were identified by NEFERMtest24 (Pliva-Lachema, Czech Republic) and selected as resistant to clinically used beta-lactam antibiotics. Resistance to antimicrobial agents was determined by standard disk diffusion method according to the NCCLS recommendations. The following antimicrobials were tested: mezlocillin, ticarcillin, piperacillin, carbenicillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin-clavulanic acid, ceftazidime, cefepime, cefoperazone, cefotaxime, ceftriaxone, ceftizoxime, moxalactam, imipenem, meropenem, aztreonam, gentamicin, amikacin, tobramycin, netilmicin, tetracycline, doxycycline, minocycline, ciprofloxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, gatifloxacin, chloramphenicol, trimethoprim-sulfamethoxazole, sulfonamides.
In the set of 37 clinical isolates 100.0 % were resistant to mezlocillin, 86.5 % to ticarcillin, 100.0 % to piperacillin, 100.0 % to carbenicillin, 10.8 % to ampicillin-sulbactam, 43.2 % to piperacillin-tazobactam, 32.4 % to ticarcillin-clavulanic acid, 56.8 % to ceftazidime, 21.6 % to cefepime, 100.0 % cefoperazone, 75.7 % to cefotaxime, 75.7 % to ceftriaxone, 86.5 % to ceftizoxime, 75.7 % to moxalactam, 0.0 % to imipenem, 0.0 % to meropenem, 59.5 % to aztreonam, 100.0 % to gentamicin, 62.1 % to amikacin, 10.8 % to tobramycin, 5.4 % to netilmicin, 100.0 % to tetracycline, 54.1 % to doxycycline, 45.9 % to minocycline, 100.0 % to ciprofloxacin, 78.4 % to levofloxacin, 100.0 % to lomefloxacin, 100.0 % to norfloxacin, 43.2 % to ofloxacin, 83.8 % to gatifloxacin, 100.0 % to chloramphenicol, 59.5 % to trimethoprim-sulfamethoxazole and 86.5 % to sulfonamides.
More than 75 % of the clinical isolates were resistant to 20 or more from 33 antimicrobial agents tested. Carbapenems (imipenem and meropenem) were the only antimicrobial agents effective to all clinical isolates.
|Session name:||XXIst ISTH Congress|
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