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The influence of severe early-onset infections on dynamic changes of serum gastrin concentration in full-term and pre-term neonates

Abstract number: 1134_03_23

Behrendt J., Stojewska M., Karpe J., Sadownik B., Godula-Stuglik U.

Objectives:  

To evaluate the influence of early-onset sepsis and pneumonia on serum gastrin concentration (s.g.c.) in the neonates according to their gestational age and to find out the relation between the functional disorders of the alimentary tract and s.g.c.

Methods:  

The study population consisted of 74 neonates (45 boys, 29 girls), among them 42 full-term (25 infected, 17 healthy) and 32 preterm (20 infected, 12 healthy) Sepsis in 23 cases (11 due to staphyloccocal strains: Staph. haemolyticus, hominis, epidermidis and aureus, 12 due to gram-negative bacteria: Klebsiellapn. 5 cases, Pseudomonas aerug.-3 cases, Enterobacter-2 cases, Haemophilus latens-1 case, Acinetobacter baumanii-1 case) and pneumonia in 22 cases were diagnosed. Main clinical signs of sepsis: gastrointestinal disorders and pneumonia were observed in all cases. Septic shock and DIC syndrome in 63%, intensive jaundice with hepatosplenomegaly in 75% and purulent meningitis in 25% of septic neonates was noted. The functional disorders were noted in 34 infected neonates (in 20 with sepsis, in 14 with pneumonia). S.g.c. (pg/ml) was determined in peripheral vein blood twice (first between 3rd and 4th day of life and second between 14th and 21st day of life) using radioimmunologic method with ready DCT sets.

Results:  

In the first week of life infected full-term neonates had significantly (p < 0.001) higher mean s.g.c. (29.38 ± 10.27, ranged from 11.90 to 67.90) than healthy (14.76 ± 3.24, ranged from 11.46 to 19.96) and infected prematures (19.29 ± 19.26, ranged from 11.45 to 21.32). The infected prematures in 3rd week of life had significantly higher mean s.g.c. (120.03 ± 32.03, ranged from 87.84 to 167.71) than the healthy ones (61.72 ± 23.51, ranged from 46.39 to 113.38) and infected full-term neonates (88.99 ± 29.44, ranged from 35.91 to 133.72). The mean value of s.g.c. in first determination in infected premature neonates with functional disorders of alimentary tract was significantly higher than in infected prematures without these symptoms. In second determination, the mean s.g.c. in full-term infected neonates with alimentary tract disorders (79.09 ± 22.37) was lower (p < 0.005) than in full-term neonates without such disorders (114.47 ± 31.56).

Conclusion:  

The dynamic changes in serum gastrin concentration in course of severe early-onset neonatal infections, observed in first month of life, both in full-term and preterm newborns, indicate its function on alimentary tract disorders.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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