The development of antimicrobial resistance in German hospitals

Abstract number: 1134_02_260

Huppertz K., Beer J., Noll I., Pfister W., Pietzcker T., Schubert S., Wichelhaus T.A., Ziesing S., Wiedemann B.


Since the end of 2001, six laboratories for medical microbiology at German university hospitals are taking part in the GENARS-project (German Network for Antimicrobial Resistance Surveillance). These laboratories regularly send data obtained in the laboratory routine to the central office of GENARS in Bonn. Here they are merged in the database and analysed. The goal of this investigation was to find out, if significant trends in the development of antimicrobial resistance in GENARS-hospitals are detectable.


MIC-values from species listed were determined for 25 antibiotics, considering all relevant antibiotic classes: E. coli, E. cloacae, P. mirabilis (ciprofloxacin, gentamicin, ampicillin, piperacillin and cefotaxime), P. aeruginosa (ciprofloxacin, imipenem, ceftazidime, gentamicin and piperacillin) and S. aureus (penicillin, oxacillin, erythromycin, doxycyclin und linezolid). Only the values of non-copy strains of five GENARS hospitals entered the statistics.


For many antibiotic–species-pairs no obvious trends could be detected. However some species show continuous changes in their resistance rates. A highly significant increase in ciprofloxacin resistant strains of E. coli and P. aeruginosa could be observed. Detailed percentages of resistant strains for the 1st half of 2002 and the 1st half of 2004 are shown in Table 1. For S. aureus strains resistant to Oxacillin (MRSA) increased significantly to a level of 11.6 % (Table 1). In means for all GENARS-hospitals the resistance rate to Oxacillin increased. Nevertheless, in two of these hospitals a clear decrease was observed. The level of resistance and resistance development for all species evaluated can vary considerably from hospital to hospital.


In the time under observation, in GENARS-hospitals for most of the selected species and antibiotics no significant changes in antimicrobial resistance could be detected. Nevertheless, as shown for E. coli and P. aeruginosa resistance to ciprofloxacin and for S. aureus resistance to oxacillin increased significantly. This demonstrates that an early detection of any alterations in antimicrobial resistance by a continuous surveillance is of great importance.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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