The susceptibility of coagulase-negative staphylococci in a teaching hospital compared with a secondary care hospital
Abstract number: 1134_02_165
Sloos J.H., Dijkshoorn L., Bax N.M., Bernards A.T., van Strijen E., van den Broek P.H.
To compare the susceptibility of coagulase-negative staphylococci (CoNS) for teicoplanine (T) and vancomycine (V) in two hospitals, the Leiden University Medical Center (LUMC) and Medical Center Alkmaar (MCA), in which these antibiotics are respectively the first choice antibiotics in serious infections with these species.
Antibiotics tested were T, V, ciprofloxacin (C), moxifloxacin (M), levofloxacin (L), and linezolid (Li). Collections I comprised 44 isolates and were from the LUMC, whereas collection II comprised 27 isolates from the MCA. Susceptibilities were determined by agar dilution on Mueller Hinton agar.
In total, six different species were identified in 71 isolates, 72% of which were Staphylococcus epidermidis. In the LUMC the species diversity was greater than in the MCA, with five isolates of Staphylococcus haemolyticus found in the first. No difference between the two hospitals was found in activity of the antibiotics tested, except for Li. The MIC90s were as follows: V 2 mg / L, T 4 mg / L, C 16 mg / L, M 2 mg / L, L 8 mg / L. Of Li the MIC90 was 2 mg / L in the LUMC and 1 mg / L in the MCA. According to Dutch guidelines, in total 7 / 71 isolates were found resistant to T and 21 intermediate resistant. All isolates were susceptible for V.
The first choice glycopeptide for serious CoNS infections, T or V, has no influence on the susceptibility of CoNS for these antibiotics. According to Dutch guidelines, the activity of T, C, and L against CoNS is relatively low, whereas the activity of M and Le is in the susceptible range.
|Session name:||XXIst ISTH Congress|
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