Understanding the Staphylococcus aureus nasal colonisation of HIV outpatients based on DNA genotyping
Abstract number: 1134_02_159
Padoveze M.C., Pedro R., Blum-Menezes D., Bratfich O.J., Moretti M.L.
AIDS patients are a special population related with high risk of infection due to Staphylococcus aureus. Previous colonization is a recognized predisposing factor for development of infection due to this organism. However, nasal carriage of S. aureus in HIV-patients is still not completely characterized.
To describe the epidemiological features of community-acquired S. aureus nasal colonization in out care HIV-patients based on the molecular genotypes.
HIV-outpatients without previous hospitalization within the last two years were screened for S. aureus nasal colonization. Three samples from each patient were collected, and the variables associated with colonization were assessed. Nasal carriage was classified as: absent, transient colonization or persistent colonization. The persistent colonization was assessed according to the molecular profiles performed by Pulsed-Field Gel Electrophoresis, in: simple (same profile), multiple (different profiles) or combined (two with the same e and one with different profiles).
111 patients were enrolled in the study. Seventy patients (63%) had at least one culture positive for S. aureus and 99 patients concluded three samples collection. Only one isolate was a community acquired MRSA. The rates of colonization was higher when two or more samples were taken, ranging from 45.5% in the first sample up to 65.6% when 3 samples were collected. HIV-patients with AIDS were more likely to be colonized than non-AIDS patients (p=0.02). Among the patients with S. aureus nasal carriage, 39% were transient and 61% were persistent carriers, whose genomic subtype was: 61.5% simple, 20.5% combined and 18% multiple persistent colonization. Previous use of antibiotics was associated with absence of S. aureus colonization (p < 0.05).
HIV out care patients had high rates of oxacillin-susceptible S. aureus nasal colonization. Regardless, the recent literature, only one isolate was community-acquired MRSA. The most common characteristic of colonization is simple persistent colonization showing the same genomic profile.
|Session name:||XXIst ISTH Congress|
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