Trichosporon beigelii as a life-threatening pathogen in bone marrow transplantation recipients: the first case report from Iran

Abstract number: 1134_02_126

Ghiasian S.A., Maghsood A.H.

Patients undergoing bone marrow transplantation (BMT) are profoundly immunosuppressed as a result of their intensive chemotherapy and are at high risk for opportunistic fungal infections mainly caused by Candida spp and Aspergillus spp. Trichosporon beigelii (T. beigelii) has emerged as a life-threatening opportunistic pathogen in immunocompromised hosts. Response to antifungal agents is poor, mortality is high and immunological recovery is the most important factor for a favorable outcome in patients with trichosporonosis. We present the first case of T. beigelii infection in patients undergoing allogeneic BMT in Iran. A 12-year-old female presented with aplastic anemia, cough and fever. She had received cytotoxic drug therapy, broad spectrum antibiotics and was neutropenic. T. beigelii was repeatedly demonstrated by appropriate morphological and physiological characteristics in her sputum, nose and mouth ulcers by direct microscopy and culture, and also isolated and histopathologically recognized in post-mortem from lung and liver. Trichosporonosis is likely to be recognized more frequently than apparent from the available reports.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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