The serum/pleural IL-6 ratio in the differential diagnosis of the tuberculous pleural effusion

Abstract number: 1134_01_163

Christopoulos A., Fengou E., Katsarou I., Ikonomopoulou E., Papadopoulos K., Rengli A.


Interleukin 6 (IL-6) is locally produced at the sites of inflammation of the pleural space. Pleural IL-6 leaks to circulation to cause its systematic effects. The amount of IL-6 produced in the pleural space as well as the amount that leaks to circulation depends on the particular disease.


To study the serum/pleural IL-6 ratio as a specific marker in the diagnosis of tuberculous pleural effusion.


Patients: IL-6 value was assessed in 77 serum/pleural fluid pair samples from patients with exudative pleural effusions with Quantakine IL-6 Immunoassay (4.5 hour solid phase ELISA).


The serum/pleural IL-6 ratio was always <=0.01 in tuberculous, >=0.1 in malignant (with exception mesotheliomas) and >=0.02 in parapneumonics pleural effusions. Pleural IL-6 was >100 U/ml in all par pneumonic and <100 U/ml in all malignant effusions.


Serum/pleural IL-6 ratio in association with pleural fluid's value is a specific and sensitive marker for the quick diagnosis of the tuberculous pleural effusion.

Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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