Another white spot on the Europe map is gone: first results of the Russian monitoring of antimicrobial consumption

Abstract number: 1134_01_122

Stratchounski L., Bedenkov A., Ishmukhametov A., Denisova M., Abramenko L., Gotovats S.

Objectives:  

The joint project of the Institute of Antimicrobial Chemotherapy and The Remedium Group of Companies (TRGC) was established to monitor the patterns of antimicrobial (AM) consumption in Russia with a long term aim to improve prescription habits and reduce antimicrobial resistance.

Methods:  

Data on the use of AM in Russia were collected from the national projects Retail Pharmaceutical Market Audit and Hospital Audit that are conducted by TRGC since 2000. The pharmacy and hospital audits are realized in 51 and 27 regions of Russia, respectively. Imprecision of the data of both audits does not exceed 10%. The final reports contain products names, Anatomical Therapeutic Chemical classification codes, drug forms, dosages and packages quantity. The use of AM was expressed as the number of defined daily doses (DDD) per 1000 inhabitants per day – DDD/1000 inhabitants/day (DID).

Results:  

The mean total consumption of AM for systemic use (J01) in 2001–2002 in Russia was 11.9 DID (2001 – 12.0, 2002 – 11.8). The use of tetracyclines (J01A), amphenicols (J01B), beta-lactams, penicillins (J01C), other beta-lactams (J01D), sulfonamides and trimethoprim (J01E), macrolides, lincosamides and streptogramins (J01F), aminoglycosides (J01G), quinolones (J01M), other antibacterials (J01X) was, respectively, in 2001 – 1.88, 0.38, 3.71, 0.30, 1.92, 1.03, 0.99, 1.00, 0.81 DID and in 2002 – 2.12, 0.47, 2.90, 0.41, 1.97, 1.04, 0.81, 1.14, 0.97 DID. Among J01C group aminopenicillins were prescribed above all (57.4% in 2001, 63.4% in 2002) and their use in 2001 was 2.13 DID and in 2002 - 1.84 DID. From 2001 to 2002, the use of ampicillin decreased from 1.67 to 1.10 DID. However, its oral form was mainly prescribed (2001 – 1.3 DID, 76.5%, 2002 – 0.81 DID, 72.7%). Whereas, the consumption of amoxicillin increased from 0.46 DID in 2001 to 0.74 DID in 2002. Cephalosporins use increased from 0.29 DID in 2001 to 0.40 DID in 2002. Between J01F AM macrolides were the most often prescribed group with 0.84 DID in 2001 (81.6%) and 2002 (80.8%).

Conclusions:  

Data on antibiotic consumption on a country level could be applied for improvement of the usage patterns.