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Beijing genotype in Bilbao

Abstract number: 903_r2350

Barrios J.L.

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Introduction:

Due to the notifications of an increment in the number of multirresistant Mycobacterium tuberculosis around the world, the objective of our work was to know the situation of this trouble in our hospital. This centre is Basurto's Hospital, a tertiary Hospital with 800 beds that give cover to the area of Bilbao.

Material and methods:

We have realised a retrospective study of the sensibility of M. tuberculosis in our hospital since 1998–2002. The used method to know the sensibility was Susceptibility Test Kit of BIO RAD® based in Cannetti's proportions method, and since 1999 we started use the liquid system BD BACTEC®MGIT 960, both of them following the maker instructions. MGIT 960 utilises these concentrations of antibiotics: isoniazid (I) (0.1 mg/mL), rifampin (R) (1.00 mg/mL), ethambutol (E) (5.00 mg/mL), streptomycin (S) (1.00 mg/mL) and pyrazinamide (P) (100 mg/mL). We have considered multirresistance if appear resistance for two first line tuberculostatics.

Results:

For the 365 studied isolates, we only have found one multirresistant isolate. This resistant was for all first line tuberculostatics (I, R, E, S and P). The case was a male of 55 years old, VIH-, smoker and moderate drinker, worked as host. His antecedents were: Pleuritis 35 years ago and some residual pulmonary images in chest radiography. Before the patients got admitted in the hospital suffered a subacute syndrome based in: chest pain, cough with mucous expectoration ocassionally green and without fever. In the day of his ingress had sputums with blood. In the chest radiography were observed calcified nodular images in left lung and cavitated infiltrate in upper right lobule. They instaurated treatment with I, R and P but was changed due to Microbiology Service informs and reiterated positive baciloscopes. The resistant was primary for all of them and the genotypic study confirmed that was Beijing genotype.

Conclusions:

In our medium is still very small the number of multi-resistant stems (1/365) being more frequent the resistant for one tuberculostatic as I (7%) or R (1.1%). Our case was a 55 years smoker male, host and without interest antecedents who presented a subacute pulmonary syndrome. We do not know any transmission from the patient to his contact group. Presented primary resistant for all first line tuberculostatics and the genotypic study showed that it was Beijing type.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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