Fluoroquinolones in Gram-negative bacilli meningitis

Abstract number: 903_r2003

Leca D.


To study the effectiveness and tolerance of fluoroquinolones in the treatment of Gram-negative bacilli meningitis

Material and methods:

During 1997–2003 we conducted a retrospective study, about 19 patients (15 males and four females, aged from 9 month to 73 years) with Gram-negative bacilli meningitis, treated with fluoroquinolones.


The meningitis was postneurosurgery in nine cases, post-traumatic in three cases and othogenic in two cases. The germs (Escherichia coli, five cases; Proteus mirabilis, two cases; Klebsiella pneumoniae, six cases; Acinetobacter baumanii, three cases; Salmonella, one case) were multiresistants to antibiotics, but susceptible to fluoroquinolones. The fluoroquinolones (pefloxacine, 13 cases, ciprofloxacine, six cases) was administered by first intention in 16 cases, with synergic antibiotics association, for 13–30 days period. The clinical parameters were normalized after 7–10 days and laboratory parameters after 2 weeks of antibiotic therapy. The evolution was favourable in 13 cases, with complications in six cases (cerebral abcess, one case; subdural empiema, one case; hydrocephalus, three cases, deft, one case and two deceased. We registered four side-effects (increase TGP, one case; digestive, two cases; rash, one case).


Fluoroquinolones are effectiveness and well tolerated in the treatment of Gram-negative bacilli meningitis in associations with synergic antibiotics.


Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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