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Early laboratory diagnosis of pulmonary tuberculosis. How to evaluate the results?

Abstract number: 902_p1479

Lago J.

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Objective:

The culture examination in Lowenstein–Jensen media, although inexpensive and specific, requires several weeks since growth of Mycobacterium tuberculosis species relatively to the MB/BacT system. The aim of this study was to evaluate the efficacy of the MB/BacT culture system in pulmonary tuberculosis patients.

Methods:

The authors realised a retrospective study of 22 clinical cases with pulmonary tuberculosis which diagnosis was confirmed by the mycobacteriologic test of sputum, bronchial aspirate and/or bronchoalveolar lavage. To evaluate the efficacy, we used the chi-square test relatively to the recovery rate, and the t student test to the detection time.

Results:

The mean age was 52.5 ± 20.6 years and 15 were male. The major symptoms were productive cough (95.4%) and vespertine fever (72.3%). By the radiological image, 36.4% had pulmonary tuberculosis that was very extensive. Relative to the examination of the culture, we verified that in 18 patients the Lowenstein–Jensen media was positive with 81.8% of sensibility, while in the MB/BacT system the sensibility was more elevated, 95.5% (P < 0.0001). The detection time in MB/BacT system was 14.0 ± 9.2 days and in LJ media 23.0 ± 5.0 days (P < 0.0001).

Conclusions:

The MB/BacT system had a higher recovery rate and a lower detection time than Lowenstein–Jensen media and could be applied as a routine method to detection of M. tuberculosis.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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