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The assessment of 3 years of routine vaccination against Haemophilus influenzae b in the Czech Republic

Abstract number: 902_p1203

Lebedova V.

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Objectives:

Routine vaccination against Haemophilus influenzae b (Hib) of infants using tetravalent DiTePe+Hib vaccine was introduced in the Czech Republic in July 2001. Three years before the introduction of this mass vaccination the nation-wide active surveillance of invasive diseases caused by Hib was introduced. These conditions provided an excellent possibility to assess the impact of routine vaccination against Hib.

Methods:

The active surveillance was introduced in January 1999 and case definition of invasive Hib disease included meningitis, epiglottitis, bacteraemia and/or sepsis, pneumonia and arthritis. According to the laboratory results, Hib cases were defined as confirmed, probable and suspected. After the introduction of routine Hib vaccination of infants, the surveillance was extended by the reporting of Hib vaccination failure (three categories according to the classification used in the UK): true vaccine failure, apparent vaccine failure and possible vaccine failure.

Results:

A total incidence of Hib invasive disease ranged between 1.0 and 1.1/100 000 population before the introduction of routine Hib vaccination (in 1999 and 2000). The highest incidences in both years were in the age groups 0–11 months (17.1/100 000, and 15.6/100 000, respectively) and 1–4 years (17.4/100 000, and 20.9/100 000, respectively). The active surveillance data for 2001–2003 indicate the decrease of Hib invasive disease in the target age group (0–11 months) after the introduction of routine Hib vaccination, in which the age specific morbidity was 15.6/100 000 in 2001, 3.3/100 000 in 2002 and 3.3/100 000 in 2003 (preliminary data for 2003). Data of vaccine failure are as follows: one case of possible vaccine failure in 2001, no vaccine failure in 2002 and two true vaccine failures in 2003 (preliminary data for 2003).

Conclusion:

Routine Hib vaccination of infants was introduced in the Czech Republic in July 2001. The results of active surveillance indicate rapid decrease of Hib invasive disease in the target age group under the influence of this mass vaccination. Hib vaccine failure is very rare.

Acknowledgement:

This study was supported by research grant NI/6803-3 of the Internal Grant Agency of the Ministry of Health of the Czech Republic.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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