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Hepatitis D super infection that developed due to endoscopy

Abstract number: 902_p1084

Yildiz Zeyrek F.

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Objectives:

Hepatitis D (HDV) is a defective virus. It uses hepatitis B surface antigen (HBs) for being an infectious agent. In chronic HBV cases if super infection develops it leads to chronic HDV in 90% of the cases. In a follow-up study of three sustained responded chronic HBV patients to therapy with interferon plus lamivudin were analysed and HDV superinfection was observed after endoscopic instrumentations.

Methods:

Anti HDV positivity and elevations in liver enzymes were observed in three patients aged between 38 and 53. They had been analysed with endoscopy. One case had been analysed with maxillary sinus endoscopy and two cases with gastroendoscopy.

Results:

After 8–18 weeks anti-HDV IgG–IgM positivity was observed by EIA (Sorin Italy). There was no way of transmission of HDV. Three cases were diagnosed as chronic HDV through clinical, virological (anti-HBs IgM and HBV-DNA negative) and histological (liver biopsy) techniques. Ten million units interferon has been used for 1 year three times a week. At the and of treatment in both these cases anti-HDV markers were negative and liver enzymes of patients were normal and only one patient had positive anti-HBs:25 IU/mL. Other two cases have been followed for HBs, anti-HBe, anti-HBc IgG which were positive, but HBV-DNA negative and live normal level.

Conclusions:

Endoscopic trials in chronic HBV patients can be a transmission way of HDV superinfection.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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